Sander Puri, Ryan Jarvis and Ryan Bowman are among the new signings who could make their debuts against the Cobblers.
Minstermen boss Nigel Worthington has all nine of his summer recruits available apart from former Burnley forward Wes Fletcher, who turned his ankle in the recent friendly against Blackpool.
Defender Ben Davies, on loan from Preston, is a likely starter, while Craig Clay and Lewis Montrose, signed from Chesterfield and Gillingham respectively, as well as teenager Tom Platt are vying for a place in midfield.
Richard Cresswell, another permanent signing following his loan spell from Sheffield United last season, is expected to be in the starting line-up, while Worthington must choose between Michael Ingham and Blackpool loanee Chris Kettings in goal.
Visiting boss Aidy Boothroyd could hand debuts to as many as eight new players on the opening day.
Former Hull and Bradford goalkeeper Matt Duke is expected to start, while veteran defender Kevin Amankwaah should also feature at the back alongside Matt Heath.
Midfielders Ian Morris, Darren Carter, Danny Emerton and Gary Deegan are all vying for places in the middle, while former Newcastle striker JJ Hooper could start in attack.
Boothroyd will be without skipper Kelvin Langmead for up to three months after he suffered a knee injury in pre-season.