Zakuani had to be replaced during last weekend’s 2-2 draw with Middlesbrough with a groin injury and he is not expected to be passed fit to continue at right-back.
Utility-man Charlie Lee replaced him against Gordon Strachan’s side but is struggling with a dead leg so Krystian Pearce may be drafted in.
New signings Ryan Bennett, Exodus Geohaghon and Scott Griffiths will complete an inexperienced back four.
Winger Chris Whelpdale missed out last Saturday with a groin strain and remains a doubt while Shaun Batt will be hoping for a start after coming on to score a stunning equaliser.
George Boyd will continue to don the captain’s armband under Cooper after scoring his 11th goal of the season against Boro.