Plymouth will begin the 2012/13 League Two campaign at home to Aldershot on August 18.
Argyle then have back-to-back away matches against Dagenham (August 21) and Oxford (August 25).
A trip to newly-promoted Fleetwood is on November 17 with last season's Conference champions set to visit Home Park on March 16.
Plymouth face both west country rivals Torquay (September 8 and December 26) and Exeter (December 15 and March 30) this campaign following the Grecians' relegation.
Argyle are scheduled to close the season with a trip to Rochdale on April 27.