Hull City will again be without Allan McGregor against Southampton as he serves the final game of his three-match suspension, so Steve Harper will continue in goal.
Steve Bruce is also likely to name Sone Aluko on the bench again as the striker continues his comeback from an achilles injury.
Full-back Liam Rosenior is also a doubt for the visit of the Saints after he was forced off with a thigh problem in the weekend victory over Sunderland.
Bruce will also be without James Chester as he continues his recovery from a hamstring injury.
Southampton boss Mauricio Pochettino will again be without Gaston Ramirez and Dejan Lovren as they continue their rehabilitation from their respective ankle injuries.
Victor Wanyama will be in contention following his recovery from a hairline fracture.
Rickie Lambert will again be in contention after his weekend return against Stoke, in which he scored a free-kick on his comeback from a hamstring injury.