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Rangers will be without Maurice Edu and Sasa Papac for the game against the Jambos.
The pair are both suspended for the clash at Ibrox, while the Scottish champions are sweating over the fitness of Lee Wallace after he missed last week's win at Inverness with a knock.
Kyle Bartley, Kyle Lafferty, Steven Whittaker and Steven Naismith remain on the sidelines through injury.
Defenders Andy Webster and Marius Zaliukas are set to return for Hearts.
Webster is available following suspension and captain Zaliukas should be fit despite going off during last week's loss to Dundee United with a knee injury, while midfielders Ian Black (ribs) and Adrian Mrowiec (knee) could return.
Striker Craig Beattie could be in contention for his debut, but winger David Templeton (groin) remains out alongside goalkeeper Marian Kello, whose dispute with the board is ongoing, and long-term absentee Kevin Kyle (hip).
Rangers (from): McGregor, Bocanegra, Goian, Broadfoot, Perry, Davis, McCulloch, Aluko, Hemmings, Kerkar, Celik, Little, Wylde, Bedoya, Healy, Alexander, McCabe, Wallace.
Hearts (from): MacDonald, Barr, Hamill, Grainger, McGowan, Webster, Zaliukas, Mrowiec, Robinson, Skacel, Novikovas, Elliott, Obua, Santana, Smith, Glen, Taouil, Driver, Ridgers, Holt, Beattie, Black.
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