Wycombe manager Gary Waddock is set to make changes.
Waddock feels he needs to freshen things up after a 4-1 defeat at relegation rivals Scunthorpe on Saturday saw Wanderers slip back to the bottom of the table.
"We have two home games now and we have to go into them in the right frame of mind," Waddock told the club's official website. "You want performances to be consistent but Saturday was very low so we will have to see what turns up on Tuesday evening.
"I will have to take a look at the team and try to freshen it up. I keep going back to the drawing board and I will have to do it again."
Defenders Danny Foster and Leon Johnson, midfielders Gareth Ainsworth and Matt Bloomfield and striker Ben Strevens are options for Waddock.
Stuart Beavon missed out at Glanford Park after sustaining a groin injury in training towards the end of last week and the forward remains a doubt.
Solomon Taiwo will be missing from the Leyton Orient squad.
The on-loan Cardiff midfielder starts a three-match ban after he was sent off in Saturday's 1-1 draw with Walsall.
Taiwo was only on the pitch as a replacement for Ryan Dickson, who hobbled off early on with a thigh injury.
Left-back Dickson could miss out against Wycombe so Dean Leacock, who started in midfield on Saturday, may have to revert to defence.
Jamie Jones (wrist) and Lee Butcher (knee) are still out so West Ham loanee Marek Stech continues in goal.
Striker Calvin Andrew could make his full debut after coming on as a late substitute against the Saddlers following his loan switch from Crystal Palace.
Any reproduction, publication or redistribution of this material without the written agreement of 365 Media Group is strictly forbidden.