Wigan striker Hugo Rodallega, who has been out for the past month with a knee injury, is making good progress but next Monday's trip to Arsenal is thought to be a more realistic target.
Fellow forward Victor Moses is fit after suffering a slight knock at Chelsea on Saturday while midfielder David Jones is also close to match fitness.
Manchester United, meanwhile, are expected to make changes as they look to extend an eight-match winning run.
Tom Cleverley and Chris Smalling will be amongst those hoping for a start, with Paul Scholes and Rio Ferdinand likely to be rested for the overwhelming title favourites.
Nani (ankle) is fit but did not even make the bench against QPR on Sunday.
Wigan (from): Al Habsi, Kirkland, Caldwell, Boyce, Figueroa, Alcaraz, Gohouri, Stam, Lopez, Beausejour, Watson, Moses, Crusat, McArthur, McCarthy, Jones, Gomez, Thomas, Diame, Maloney, Sammon, Di Santo.
Manchester United (from): De Gea, Amos, Rafael, Jones, Smalling, Ferdinand, Evans, Fabio, Evra, Valencia, Nani, Park, Scholes, Cleverley, Carrick, Pogba, Giggs, Young, Rooney, Welbeck, Hernandez, Berbatov.
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