Cristiano Ronaldo scored a hat-trick while Gareth Bale scored twice as Real Madrid hammered Deportivo La Coruna 8-2.
Bayern Munich dropped Bundesliga points for only the second time this season, as Borussia Dortmund were defeated.
Juventus confirmed they are still the team to beat in Serie A, ending AC Milan's perfect start to the season with a 1-0 win at San Siro.
Marseille striker Andre-Pierre Gignac's brace in 3-0 win over Rennes lifts them to joint top in Ligue 1.
Heerenveen made it five games without defeat as they drew at Vitesse Arnhem, while FC Dordrecht grabbed an away point.
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"Opposition fans are more than welcome to lay into us and I wouldn't blame. 2 Saturday's of mine spoiled...."