Paul Pogba has suffered a setback in his recovery from an ankle injury and will miss Manchester United’s date with Liverpool on Sunday, while David de Gea will also be sidelined.
De Gea picked up a groin injury in Spain’s European 2020 qualifier with Sweden on Tuesday and needs to have a scan to determine the extent of the problem.
“David needs a scan,” Solskjaer told Sky Sports. “I think he’ll be out. It certainly looked like it anyway judging on last night so it’s just one of those things.
The keeper’s absence means Sergio Romero will step up to make his first league start of the season.
De Gea is joined on the sidelines by Pogba and Jesse Lingard as United’s problems show no sign of ending.
Pogba has been in and out of the team since picking up an ankle problem against Southampton on August 31 but the Frenchman spent part of the international break in Dubai focusing on his recovery and was set to be fit for the match.
Solskjaer added: “Paul had an injury, he came back, he worked really hard. He came back and played a couple of games, maybe played through the pain barrier.
“He had a scan after the Arsenal game and maybe needed a few weeks’ rest in a boot so hopefully he won’t be too long, but he won’t make this game, no.”
United could welcome back Anthony Martial, Luke Shaw and Aaron Wan-Bissaka though.
Solskjaer said: “I can’t tell you 100 per cent [who] is going to be fit as something might happen.
“But hopefully Aaron and Anthony will last the training this week and be available for selection. If it’s for half a game or 30 minutes I don’t know but let’s see where they’re at.”