Ill Schurrle misses out
The German Football Association (DFB) confirmed the news on its website just hours before the Group D clash at the Veltins Arena in what is a further blow for coach Joachim Low – now without six of his World Cup winners.
Schurrle joined captain Bastian Schweinsteiger, Christoph Kramer, Mesut Ozil, Benedikt Howedes and Sami Khedira on the sidelines.
The world champions face the Republic having surrendered a 33-game unbeaten run in qualifiers with a 2-0 defeat in Poland on Saturday – a result which followed a friendly loss to Argentina and a narrow victory over Scotland in Euro qualifying.
Germany sit third in the pool, three points behind Poland and the Republic, who are joint top after two wins each.
Low insisted he would not make too many changes to his team, although Schalke’s Julian Draxler is expected to be drafted in on his home ground after shaking off a virus.
Watch Germany’s clash against the Republic of Ireland in Gelsenkirchen in the European Qualifiers live on Sky Sports 5 HD on Tuesday night, with coverage underway from 7pm.