Orient, now managed by former Barnet boss Ian Hendon, were relegated from League One last season while Barnet are back in the Football League after winning the Vanarama Conference.
Bristol Rovers are also back in League Two after winning the Conference play-off final on penalties and they start with a home match against Northampton.
Title favourites Portsmouth will hope this is the season they can start to climb back up the divisions and they begin life under new boss Paul Cook at home to Dagenham & Redbridge, while Oxford, who are also well-fancied, kick-off at home to Crawley.
Wycombe suffered an agonising penalty shoot-out loss in the League Two play-off final last month, and they start their season with a visit from York.
Former England international Teddy Sheringham is the new manager at Stevenage and they welcome Notts County on opening day, Terry Butcher begins life in charge at Newport with a trip to Cambridge and Derek Adams’ reign at Plymouth begins at AFC Wimbledon.
Opening day fixtures (8 August):
AFC Wimbledon v Plymouth Argyle
Accrington Stanley v Luton Town
Bristol Rovers v Northampton Town
Cambridge United v Newport County
Exeter City v Yeovil Town
Hartlepool United v Morecambe
Leyton Orient v Barnet
Mansfield Town v Carlisle United
Oxford United v Crawley Town
Portsmouth v Dagenham & Redbridge
Stevenage v Notts. County
Wycombe Wanderers v York City