All the team news ahead of the Premier League weekend, with Man Utd given a clean bill of health and a raft of debutants set to feature.
Manchester United v Manchester City
Saturday, 12:30, Old Trafford
Henrikh Mkhitaryan, Luke Shaw and Antonio Valencia have all been given the green light to play for Manchester United.
Armenian playmaker Mkhitaryan was a doubt with a knee complaint and left-back Shaw withdrew from the England squad due to a calf issue, while fellow full-back Valencia had to be assessed after international duty with Ecuador.
Marouane Fellaini overcame a back injury in playing for Belgium on Tuesday, while Marcos Rojo and Sergio Romero are available despite convoluted journeys back from the break spent with Argentina. Marcus Rashford is pushing for a start after netting a hat-trick for England Under-21s in midweek.
Leroy Sane and Ilkay Gundogan are now fit and may make their debuts, as could goalkeeper Claudio Bravo.
Captain Vincent Kompany is back in full training following a thigh problem but the club will not rush the injury-plagued defender back to action.
Arsenal v Southampton
Saturday, 3pm, Emirates Stadium
Arsene Wenger must decide whether to hand debuts to new signings Shkodran Mustafi and Lucas Perez.
The pair signed before the international break and could both feature against Saints, with Mustafi more likely to start given Arsenal’s defensive injuries.
The involvement of Alexis Sanchez is uncertain after a late return from international duty with Chile and Alex Iwobi is fit after a thigh problem but Aaron Ramsey (hamstring), Per Mertesacker, Danny Welbeck and Carl Jenkinson (all knee) are all out.
Ryan Bertrand could be back in contention for Southampton.
The left-back has missed the opening three games of the season due to a knee problem. Goalkeeper Fraser Forster, who has had an arm injury, is back in contention.
Manager Claude Puel has said new signing Sofiane Boufal will not be part of the squad for another month whilst he works on his fitness.
Bournemouth v West Bromwich Albion
Saturday, 3pm, Vitality Stadium
Jack Wilshere is expected to make his Bournemouth debut against West Brom on Saturday.
The England midfielder joined the Cherries on loan for the rest of the season from Arsenal at the end of August and is set to feature for the first time against the Baggies.
Bournemouth could be without Josh King after the 24-year-old suffered from a hamstring problem whilst away on international duty with Norway, while manager Eddie Howe said there were a number of internationals who were facing late fitness tests but did not disclose names.
Hal Robson-Kanu will probably have to wait to make his West Brom debut as the trip to Bournemouth comes too soon for the striker.
The Wales international, who came on as a late substitute for his country on Monday, is short of match fitness and Baggies boss Tony Pulis reckons it will be between 10 days and two weeks before he is up to speed. However, fellow new signing Nacer Chadli could be involved.
Chris Brunt has resumed training following his serious knee injury but he is not expected to be available again until next month.
Burnley v Hull City
Saturday, 3pm, Turf Moor
Burnley’s record signing Jeff Hendrick and new loan striker Patrick Bamford come into the squad.
Hendrick, a deadline-day capture from Derby, scored for the Republic of Ireland in midweek and could slot straight into central midfield alongside fellow new recruit Steven Defour, while Bamford may have to make do with a place on the bench.
Liverpool loanee Jon Flanagan may make a first league appearance having worked on his fitness over the international break but forward Ashley Barnes remains out with a lower hamstring issue.
Hull caretaker manager Mike Phelan could add all six new signings to his squad for Saturday’s Premier League clash at Burnley.
Phelan, who has no new injury or suspension concerns, had only 14 fit senior players for the 1-0 home defeat to Manchester United last time out, but club record signing Ryan Mason and striker Will Keane are among those hoping to feature.
Fellow new recruits, goalkeeper David Marshall, midfielders Markus Henriksen and James Weir, plus forward Dieumerci Mbokani are also in contention, while Phelan will assess Abel Hernandez following the striker’s return from international duty with Uruguay.
Middlesbrough v Crystal Palace
Saturday, 3pm, Riverside Stadium
New signings Calum Chambers and Adama Traore could be handed Middlesbrough debuts.
Arsenal defender Chambers has joined the club on a season-long loan deal, while Traore completed a permanent move from Aston Villa on deadline day and both are in contention for the weekend.
Head coach Aitor Karanka will welcome back goalkeeper Victor Valdes (hamstring), defenders George Friend (calf) and Fabio da Silva (knee) and midfielder Marten de Roon (also hamstring), leaving only long-term absentees James Husband (dislocated shoulder) and Grant Leadbitter (hernia surgery) still missing. Karanka will make late checks on Uruguay internationals Gaston Ramirez and Cristhian Stuani following their return from international duty.
Jonathan Benteke is in contention to make his Crystal Palace debut after a thigh injury ruled Loic Remy out for the next seven to eight weeks.
Palace manager Alan Pardew may also need to reshuffle his midfield, with Yohan Cabaye (groin) and James McArthur (illness) facing late fitness tests after their recent withdrawals from international duty.
Bakary Sako is close to a first-team return but Saturday may prove too soon. New signing Mathieu Flamini is similarly short of match-fitness, while Fraizer Campbell (hamstring) has been ruled out.
Stoke City v Tottenham Hotspur
Striker Wilfried Bony is poised to make his competitive Stoke debut in Saturday’s Premier League home clash with Tottenham.
Defender Bruno Martins Indi, another man signed on loan on transfer deadline day like Bony, could also make his first Potters appearance, while another, goalkeeper Lee Grant, is expected to replace Jakob Haugaard (ankle) on the bench as back-up to Shay Given.
The veteran Irishman is set for an extended run in the side as Jack Butland is out for another six to 10 weeks following ankle surgery, and winger Xherdan Shaqiri (calf) remains sidelined as well. Forward Mame Diouf (hamstring) is a doubt but full-back Glen Johnson could return to the squad having recovered from a thigh problem.
Tottenham captain Hugo Lloris will return to the side for Saturday’s Premier League trip to Stoke.
The France goalkeeper has been missing since suffering a hamstring injury on the opening day of the season but is set to replace Michel Vorm for the game.
Head coach Mauricio Pochettino has yet to decide whether new signings Moussa Sissoko and Georges-Kevin Nkoudou will start but Mousa Dembele is still suspended and Danny Rose (hamstring) is out.
West Ham United v Watford
Saturday, 3pm, London Stadium
West Ham boss Slaven Bilic is set to include fit-again Dimitri Payet and new signing Simone Zaza into the starting line-up.
France star Payet has made just one substitute appearance for the Hammers this season due to a thigh niggle but is now fully fit, and he should be joined in the team by Italy striker Zaza.
Manuel Lanzini, Sofiane Feghouli and Havard Nordtveit are also back from injuries but Andy Carroll, Andre Ayew, Aaron Cresswell and Diafra Sakho are still out and deadline-day arrival Alvaro Arbeloa is not match fit.
Watford will check on defender Craig Cathcart, who has been troubled by a groin strain, ahead of Saturday’s Premier League match at West Ham.
Defender Brice Dje Djedje is also doubtful with a foot problem, while Argentina midfielder Roberto Pereyra could make his first start, having scored when coming off the bench in the home defeat by Arsenal before the international break.
Adrian Mariappa has rejoined the Hornets after being released by Crystal Palace earlier this summer, and 20-year-old Brazilian midfielder Kenedy could be included after signing on a season loan from Chelsea.
Liverpool v Leicester City
Saturday, 5:30pm, Anfield
Liverpool midfielder Emre Can and defender Ragnar Klavan will not be fit for the visit of the Premier League champions.
The Germany international injured an ankle in the EFL Cup win over Burton on August 23 and will not be ready while Estonia centre-back Klavan reported back from international duty with a gashed and bruised knee.
Goalkeeper Loris Karius has returned to training after surgery on a broken hand and is likely to be on the bench.
Kasper Schmeichel is available after recovering from a hernia operation.
The goalkeeper came off in the Foxes’ 2-1 win over Swansea last month and missed Denmark’s 1-0 World Cup qualifying win over Armenia but is fit and will keep Ron-Robert Zieler on the bench for the Premier League match at Anfield.
Nampalys Mendy is out with an ankle injury while Jeff Schlupp will not be risked by boss Claudio Ranieri as he continues to recover from a muscle strain. Record signing Islam Slimani could make his debut after joining from Sporting Lisbon on deadline day.
Swansea City v Chelsea
Sunday, 4pm, Liberty Stadium
Swansea hope record signing Borja Baston will feature for the first time on Sunday.
The striker has struggled with a thigh injury since his £15.5million move from Atletico Madrid but he could make the bench alongside new central defender Alfie Mawson, who joined from Barnsley in a £5million deal just before the transfer deadline.
Wales full-back Neil Taylor is included in a Premier League squad for the first time this season following his extended post-Euro 2016 break and Jefferson Montero is available despite his late return from international duty with Ecuador.
David Luiz could make his first appearance for Chelsea since his deadline-day transfer from Paris St Germain in Sunday’s clash with Swansea.
Luiz completed a £34million move back to Stamford Bridge on August 31 and is available for the Premier League clash at the Liberty Stadium.
Left back Marcos Alonso also comes into contention after joining from Fiorentina, but defender Kurt Zouma remains sidelined with a knee problem.
Sunderland v Everton
Monday, 8pm, Stadium of Light
Midfielder Jan Kirchhoff could return to the Sunderland squad for Monday night’s clash with manager David Moyes’ former club Everton.
Jordan Pickford is fit after withdrawing from the England Under-21s squad with a thigh strain, as is defender John O’Shea following his return to action for the Republic of Ireland on Monday evening after a hip injury.
New signings Mika Domingues and defender Jason Denayer could also be involved, but Didier Ndong is yet to arrive on Wearside because of administrative issues and striker Victor Anichebe is not match fit.
Lee Cattermole (hernia surgery) remains on the sidelines despite his return to training and is joined by keeper Vito Mannone (elbow surgery), defender Billy Jones (hip), midfielder Sebastian Larsson (knee) and striker Fabio Borini (groin).
Forward Enner Valencia could make his Everton debut following his transfer deadline day loan switch from West Ham.
Defender Seamus Coleman is ready for his Toffees comeback having recovered from an ankle problem and featured for the Republic of Ireland during the international break.
Darron Gibson and Tom Cleverley should also be available again after recent knocks, but fellow midfielder James McCarthy remains out after undergoing groin surgery.