Jurgen Klopp could have two key players back fit, while the absence of Hugo Lloris and Joe Hart dominates Spurs’ and Man City’s pre-match headlines.
Manchester United v Southampton
Old Trafford, 8pm
Jose Mourinho could hand Paul Pogba his first appearance since his world-record transfer to Manchester United was completed when Southampton visit Old Trafford.
Despite only training for 11 days, Mourinho is confident Pogba is fit enough to feature, even if the Portuguese doubts he will be able to complete 90 minutes.
Mourinho confirmed that Jesse Lingard, who was not in the squad at Bournemouth, is free of injury while Chris Smalling returns from suspension.
Ryan Bertrand remains sidelined with knee trouble for Southampton. The 27-year-old full-back missed the season-opening 1-1 draw with Watford last weekend and is still not ready to return.
Saints have no fresh injury concerns elsewhere, with boss Claude Puel weighing up whether to start Jose Fonte at centre-back.
Stoke City v Manchester City
bet365 Stadium, 12:30pm
Xherdan Shaqiri is doubtful for Stoke as they entertain Pep Guardiola’s Manchester City at the bet365 Stadium.
The Swiss playmaker is still struggling with an ankle problem he sustained in pre-season and will be assessed on Friday, though Mark Hughes confirmed Marko Arnautovic, who scored twice against City in this fixture last term, is fine despite a thigh injury.
Goalkeeper Shay Given, 40, will likely deputise for Jack Butland (ankle) once more and Glen Johnson (quadriceps) is also out along with Stephen Ireland (broken leg) and Ibrahim Afellay (knee).
Focus remains on Joe Hart’s position as Manchester City travel to Stoke.
Hart has been left on the bench for City’s opening two matches of the season with Willy Caballero preferred but manager Pep Guardiola insists the England goalkeeper remains in contention.
Right-back Bacary Sagna could be doubtful due to a “little problem” while captain Vincent Kompany (thigh) and new midfielders Leroy Sane (hamstring) and Ilkay Gundogan (knee) remain on the sidelines.
Burnley v Liverpool
Turf Moor, 3pm
Record signing Steven Defour could make his Burnley bow against Liverpool in the Premier League on Saturday.
The 46-cap Belgium international moved to east Lancashire for £7.5million earlier this week and he may replace David Jones in the line-up after the latter joined Sheffield Wednesday.
On-loan full-back Jon Flanagan cannot feature against his parent club, though he is still working on his fitness anyway, while Ashley Barnes’ hamstring will keep him out again.
Striker Daniel Sturridge and midfielder James Milner are in contention for Liverpool after returning to training this week.
The pair missed last week’s win at Arsenal with hip and ankle problems respectively but have recovered, although forward Sadio Mane is a doubt after sustaining a shoulder injury in training.
Defender Joel Matip and Lucas Leiva (hamstring) have also rejoined the group while fellow midfielder Emre Can is pushing for a start after a substitute appearance at the Emirates.
Swansea v Hull
Liberty Stadium, 3pm
Jack Cork will take over the Swansea captaincy for Hull’s Premier League visit if Leon Britton fails to recover from illness.
Gylfi Sigurdsson is a potential starter after his Euro 2016 exploits – the Iceland playmaker came off the bench in the opening day 1-0 win at Burnley – and South Korean Ki Sung-yueng is likely to be involved after his own international and military service over the summer.
But Wales defender Neil Taylor is again omitted to build up his fitness after the Euros, while club record £15.5m signing Borja Baston misses out on making his debut after picking up a leg muscle injury in training.
Hull caretaker manager Mike Phelan will decide whether to select Harry Maguire against Swansea to help ease his defensive crisis.
Maguire returned to training in midweek but Phelan has indicated he could keep him in cotton wool for the trip after Jake Livermore filled in confidently in central defence against Leicester.
Allan McGregor (back), Alex Bruce (Achilles), Moses Odubajo (knee) and Michael Dawson (knee) all remain on the long-term injury list.
Tottenham v Crystal Palace
White Hart Lane, 3pm
Tottenham goalkeeper Hugo Lloris will miss Saturday’s game at home to Crystal Palace with a hamstring injury.
Michel Vorm will replace Lloris, who came off in the first half against Everton last weekend and is expected to be out for around four weeks.
Son Heung-min has returned from the Olympic Games following South Korea’s defeat to Honduras and will be assessed on Friday. Moussa Dembele remains suspended.
Alan Pardew is expected to recall Yohan Cabaye to Crystal Palace’s starting XI.
Cabaye was a substitute in last week’s 1-0 home defeat by West Brom, but alongside fellow midfielders James McArthur and Jordon Mutch and new defender James Tomkins, is considered to be sufficiently match fit to start.
Christian Benteke’s proposed transfer from Liverpool is set to be confirmed on Friday but not in time for him to feature at White Hart Lane. Pardew is without Yannick Bolasie and Mile Jedinak, who were both sold during the past week.
Watford v Chelsea
Vicarage Road, 3pm
Watford go into Saturday’s Premier League clash against Chelsea with no new injury worries.
Summer signings Isaac Success and Brice Dja Djedje continue to struggle with foot and leg injuries respectively, while midfielder Ben Watson will begin the first game of his three-match suspension after being sent off during Watford’s 1-1 draw at Southampton last weekend.
Sunderland defender Younes Kaboul and Juventus midfielder Robert Pereyra are both having medicals at the club and awaiting confirmation of their moves before being available to play for Walter Mazzarri’s side.
Chelsea have no fresh injury concerns ahead of Saturday’s trip to Watford.
Juan Cuadrado could be omitted from the squad again despite training on Friday, with Juventus still attempting to force a transfer for the Colombia forward.
Kurt Zouma remains sidelined with long-term knee trouble.
West Brom v Everton
The Hawthorns, 3pm
Winger Yannick Bolasie is set to make his Everton debut following his move from Crystal Palace this week.
Boss Ronald Koeman will make late calls about whether centre-back Ashley Williams has built up sufficient fitness to make his Toffees bow at the Hawthorns and if Romelu Lukaku is fit enough to be involved, the striker having returned to training on Thursday after a heel injury.
Full-back Seamus Coleman is facing another two weeks at least on the sidelines with his ankle problem.
James Morrison is fully fit for West Brom after making his return from injury in the 1-0 win at Crystal Palace last week.
The midfielder suffered a hamstring problem in January but was a late substitute at Selhurst Park and is available again for Saturday’s encounter.
Chris Brunt remains out with a serious knee injury which forced him to miss Northern Ireland’s Euro 2016 campaign but is expected to return to full training in September.
Leicester City v Arsenal
King Power Stadium, 5:30pm
Robert Huth returns to the Leicester squad to face Arsenal on Saturday after completing his three-match ban.
The defender is available following a violent conduct charge after a tangle with Marouane Fellaini at Manchester United at the end of last season.
Jeff Schlupp remains available for boss Claudio Ranieri despite interest from West Brom and the defender being left out of the squad for last week’s 2-1 opening day defeat at Hull. Gokhan Inler and Ritchie de Laet will not be included in the squad having been told they can leave the Foxes.
Sunderland v Middlesbrough
Stadium of Light, 1:30pm
Sunderland boss David Moyes will be without central defenders Lamine Kone and Younes Kaboul for Sunday’s first home game of the season against Middlesbrough.
Kone is out with a back problem with his future on Wearside still uncertain, while Watford have been given permission to speak to Kaboul after the two clubs agreed a fee for his sale.
Fabio Borini is a doubt with a toe problem, while fellow midfielder Lee Cattermole could be out of action for up to six weeks after undergoing surgery to repair a double hernia and Billy Jones (hip), Jan Kirchhoff (hamstring) and Sebastian Larsson (knee) are all still out, although Steven Pienaar could be involved after signing a one-year deal.
Middlesbrough defender Daniel Ayala could make an unexpected return to contention for Sunday’s Wear-Tees derby clash at Sunderland.
Centre-half Ayala was thought to be some distance from a return to action after being ruled out of all Boro’s pre-season games with an ankle injury – which forced him to sit out the opening-day home draw against Stoke – and boss Aitor Karanka must decide whether to pitch him straight into action.
Skipper Grant Leadbitter is still working his way back from a hernia operation and fellow midfielder Marten de Roon will be sidelined for two weeks after sustaining a hamstring strain against Stoke. Bernardo Espinosa (knee) and James Husband (shoulder) are still out.
West Ham v Bournemouth
London Stadium, 4pm
Slaven Bilic is likely to once again shuffle his pack as West Ham host Bournemouth.
The Hammers boss made a number of changes for Thursday’s Europa League play-off draw against Astra but could hand the likes of Dimitri Payet their first starts of the season.
Aaron Cresswell and Manuel Lanzini (both knee) are missing while Andre Ayew could miss four months with a thigh injury and Diafra Sakho (back) and Sofiane Feghouli (hamstring) are also absent.
Bournemouth manager Eddie Howe is expected to retain much of the team that lost to Manchester United.
Howe refused to be disheartened by their 3-1 home defeat, believing the game to have been “even”.
He remains without the injured Junior Stanislas, owing to a groin injury, while Tyrone Mings is not expected to return until September.