Writing on Twitter, Sky Sports pundit Neville responded to reports that United could be lining up a 40million euro plus De Gea bid for the Real Madrid defender.
He said: “These reports saying 40m plus DDG for Ramos?? Please no! Nothing [against] Ramos but it can’t be right..”
Real Madrid have been heavily linked with Spain goalkeeper De Gea all summer, but recent reports state that United will not sell unless they can secure the services of Ramos as part of the deal.
Ramos has played for Real Madrid since 2005, winning three La Liga titles, two Copa del Reys and one Champions League title with Los Blancos.
Although Neville seems disappointed with the potential arrival of the World Cup-winning defender, fellow Monday Night Football expert Jamie Carragher believes Ramos would be an excellent addition to Louis van Gaal’s back-line.
Speaking to talkSPORT, he said: “I get a bit wound up by the criticism Ramos gets. This is a fella who has won everything, he plays for one of the best clubs in the world and one of the best international sides we’ve ever seen.
“He is rash at times, he has moments of madness and does get overly emotional in games, that’s always been a problem for him, but let’s not forget that it’s a problem for Wayne Rooney as well.
“I’m not bothered about whether United sign him or not, or whether he’d be a good signing or not, but if he is not rated as one of the world’s best players, who is?
“I think it’s disrespectful – he’s won nearly 130 caps for Spain! He’s not playing for Mickey Mouse teams!”