Tottenham defender Sergio Reguilon looks set to be out for three weeks with a muscle injury.
The left-back is due to miss Thursday night’s game with Liverpool as well as crunch clashes against Chelsea and Manchester City.
It could leave Jose Mourinho in a tight spot for the game against Liverpool as Ben Davies is also a doubt having picked up a knock in Monday’s FA Cup win at Wycombe.
Reguilon was an unused substitute in that game, with Mourinho intriguingly choosing to put centre-back Joe Rodon on to replace Davies.
Mourinho alluded to there being an injury issue in his pre-match press conference, but was keen to keep the identity of the player under wraps.
When asked about the fitness of a Ben Davies and Matt Doherty, he said: “Yeah, and we have more problems than that what I’m not going to share.
“You have to wait for tomorrow but we have a little bit of more problems than that.”
Reguilon was a summer signing from Real Madrid, arriving on the same day as Gareth Bale’s homecoming.
No advantage for Spurs, says Jose
Meanwhile, with Liverpool losing their cutting edge recently, it could be a good time for Tottenham – who have not tasted defeat since before Christmas – to face them.
However, Mourinho explained that every big club goes through tough spells, and just because it is Liverpool’s turn, does not mean it will be an easier match.
He said: “Every club, especially the traditional top six, has this situation. Not one team started with winning and is still winning after 19 matches and a few months of competition.
“Everyone has a difficult period. Some early, some later, some in the middle.
“Great evolution in the considered historically below level team and ambitions, great performances from many of them. Very good teams, very good squads. I feel completely natural that some results happen.
“No, I don’t feel that at all [that Spurs have an advantage due to Liverpool’s form]. Play Liverpool is play Liverpool, independent of all the context, independent of everything.
“I don’t feel it is an advantage and I don’t feel it is a disadvantage. Simple.”